AMAB Hypogonadism

AMAB Hypogonadism or Wolffian Hypogonadism is an intersex variation - more specifically, a form of hypogonadism - leading to a reduction in the output of wolffian sex hormones in AMAB or otherwise CTM individuals due to decreased functionality of the testes. Hypogonadism can be primary, meaning it's caused by a problem with the testicles, or it can be secondary hypogonadism, meaning it's caused by a problem with the signals sent from the brain to the testicles.

Symptoms will include the effects of low testosterone, such as low energy, fatigue, low muscle tone, and a lower sex drive (unless they are already on the ace-spectrum and/or already not sex-favorable.) Those with congenital hypogonadism are usually diagnosed because they will not have started puberty.

Causes
Hypogonadism can be congenital or it can be acquired. Acquired hypogonadism may be caused by infections, radiation, certain autoimmune disorders, some chronic illnesses, severe stress, or damage to the pituitary gland (through drugs, radiation, or surgery.)

Hypogonadism may, in some cases, be caused by gene mutations, chromosomal abnormalities, and hormonal abnormalities. It can also be caused by other intersex variations.

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